The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and marginally soluble in alcohol. The molecular pounds is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it has the following chemical composition.
Sedating medicine may well induce confusion and around-sedation during the elderly; aged people usually must be begun on lower doses of Promethazine HCl Oral Option and observed intently.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other typical measures, following the acute manifestations happen to be controlled.
Individuals must be encouraged to measure Promethazine HCl Oral Answer using an accurate measuring machine. A home teaspoon just isn't an exact measuring product and could lead to overdosage, particularly when a half a teaspoon is measured.
Codeine resembles morphine both of those structurally and pharmacologically, but its actions for the doses of codeine used therapeutically are milder, with significantly less sedation, respiratory melancholy and gastrointestinal, urinary, and pupillary effects. Codeine creates an increase in biliary tract pressure, but below morphine or meperidine. Codeine is much less constipating than morphine.
The combination of promethazine hydrochloride and codeine phosphate need to be utilized with warning in pediatric client 6 many years and older (see WARNINGS – Use in Pediatric Clients).
Thanks to equivalent pharmacologic Attributes, it really is realistic to hope similar threat with concomitant usage of opioid cough drugs and benzodiazepines, other CNS depressants, or Liquor.
Long-expression animal reports haven't been performed to assess the carcinogenic likely of Promethazine, nor are there other animal or human knowledge regarding carcinogenicity, mutagenicity, or impairment of fertility with this particular drug. Promethazine was nonmutagenic within the Salmonella exam system of Ames.
Promethazine HCl Oral Alternative might reduced seizure threshold. It should be applied with caution in folks with seizure Diseases or in folks who are using concomitant remedies, which include narcotics or neighborhood anesthetics, which may also impact seizure threshold.
Existence-threatening respiratory despair and death have happened in children who acquired codeine. The majority of the described situations occurred next tonsillectomy and/or adenoidectomy, and lots of of the youngsters experienced proof of remaining an ultra-fast metabolizer of codeine because of a CYP2D6 polymorphism [see Warnings and Safety measures (5.
It is necessary that Promethazine HCl Oral Resolution is measured with an exact measuring machine (see Safeguards-Data for Clients). A family teaspoon is not really an precise measuring unit and could lead on to overdosage, particularly when half a teaspoon is to be measured.
Promethazine shouldn't be Employed in pediatric individuals fewer than 2 several years of age because of the prospective for deadly respiratory melancholy.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people a lot less than 6 decades of age, simply because The mix may possibly trigger lethal respiratory melancholy in this age populace.
Promethazine HCl Oral Remedy may very well be made use of alone or as an adjunct to narcotic analgesics during labor (see DOSAGE AND more info ADMINISTRATION). Constrained details recommend that utilization of Promethazine HCl Oral Option throughout labor and shipping and delivery doesn't have an considerable impact on the period of labor or delivery and will not improve the hazard of require for intervention while in the new child.